d-dimer

ive been reading few things regarding d-dimer

( by courtney et al. : sensitivity 93%, specificity 51%)
-d-dimer has a very high negative predictive value

-d-dimer also need to be clinically interpretated from pretest probability)
-in high risk pt( wells score >4: d-dimer has no role in diagnosis)
high risk pt should just be asses straight by imaging

-as aforementioned, low risk pt, with -ve d-dimer , can exclute VTE

false +ve d-dimer: elderly, infection, inflammation)
false negative d-dimer in pt with pre existing on warfarin , or any anticoagulant